Raman Spectroscopy Technique Measures Blood Glucose Levels As Effectively As a Finger Prick Test

The researchers from the University of Missouri School of Medicine and the Massachusetts Institute of Technology recently evaluated the accuracy of an MIT-developed technology to monitor blood glucose levels without needles or a finger prick. Early results show that the noninvasive technology measures blood glucose levels as effectively as a finger prick test.

Raman spectroscopy is as a type of molecular spectroscopy that provides direct chemical signatures of the glucose molecules that make molecular spectroscopy a promising tool to develop noninvasive sensor technologies. Compared to any other molecular spectroscopy, Raman systems give rich specific detection and discrimination from isomers and background that also has biomarkers of skin and the blood.

The number of patients with diabetes still continues to increase. The need for regular blood glucose monitoring sparks the interest in the development of modern detection technologies. The successful development of a noninvasive blood glucose sensor that can operate reliably over sustained periods of time has been a much sought after but elusive goal in diabetes management. Since diabetes has no well-established cure, control of elevated glucose levels is crucial for avoiding severe secondary health complications in multiple organs including the retina, kidney, and vasculature. While fingerstick testing continues to be the mainstay of blood glucose detection, advances in electrochemical sensing-based minimally invasive approaches have opened the door for alternative methods that would considerably improve the quality of life for people with diabetes. Optical technologies have surfaced as attractive candidates as researchers have sought to exploit the endogenous contrast of glucose, notably its absorption, scattering, and polarization properties.

The innovative device that was developed by researchers from MIT uses a technique called Raman spectroscopy to measure the chemical composition of skin and extract the amount of glucose out of other skin compartments. A fiber cable attached to a wristband passes laser light onto the skin to detect different components in the skin, such as a sort of molecular fingerprint that can be used to determine glucose levels.

With more testing, the researchers hope Raman systems can become an alternative instrument to test glucose levels in patients in clinical care settings who are not capable of frequent blood draws and, one day, in other settings as the technology becomes smaller and more portable.

With diabetes on the rise, the development of accurate, efficient, and inexpensive alternative method to test blood glucose levels in an urgent clinical need. Raman spectroscopy has the capability of direct in situ detection of glucose with high specificity and accuracy.

Optromix Raman fiber optic probes are miniaturized without compromising its performance which is enabled by the technology of direct deposition of the dielectric filters at the fiber end faces. The fiber optic Raman probe is produced for multi-wave excitation in the range 690-785 nm and 1000-1064 nm, e.g. @785 nm – “Fingerprint” spectral range with fluorescence reduction, and @690 nm  – “High wavenumber” specific range for conventional Raman spectrometers.

If you would like to buy Optromix Raman fiber optic probes, please contact us at info@optromix.com



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